Stress, The Immune System, and The Brain
The definition of stress has evolved over time from predation and natural disasters to economic insecurity to interpersonal conflicts.
In the past, stressors were only acute (fight, flight, freeze) and now less “life-threatening”, more persistent, and chronic, and those previously labeled as “trivial” are acknowledged as stressors as well.
Stress and the immune system and its response to stress can influence the production, activation, and mobilization of immune cells-Chronic stress.
More evidence suggests that chronic stress induces a vulnerability to psychiatric disorders by altering neural circuitry.
Stress-induced changes in brain structure impact cortex, amygdala, and hippocampus morphology.